Diabetes Vaccine Officially Revealed

Diabetes is on the rise from urban to rural people due to lack of healthy life style. China, India and USA are among the top three countries with a high number of diabetic population. While the numbers climbed from

• 20.4 million in China in 1980 to 102.9 million in 2014, the rise has been equally dramatic in India from 11.9 million in 1980 to 64.5 million in India.
• Prevalence of diabetes has more than doubled for men in India and China (3.7 per cent to 9.1 per cent in India and 3.5 per cent to 9.9 per cent in China).
• It has also increased by 50 per cent among women in China (5.0 per cent to 7.6 per cent) and 80 per cent among women in India (4.6 per cent to 8.3 per cent).

Currently there is no known cure for diabetes, an autoimmune disorder that produces high blood sugar levels over a prolonged period. There are two forms of the disease, the first of which (Type 1) typically onsets during childhood and results from the body’s immune system attacking insulin-producing cells in the pancreas. Insulin is key to glucose metabolism, and the absence of insulin in the blood stream results in a build-up in the body which over time becomes life-threatening. This deficiency is primarily controlled through insulin injections.

Type 2 diabetes is often referred to as “adult onset” and, depending on the severity, can in some cases be controlled with diet and lifestyle changes. It results from cells becoming resistant to the effects of insulin and is often linked to obesity.

But the good news is that the Vaccine Against Diabetes has been officially Announced. The Vaccine versus Diabetes has been formally revealed at the 75th Scientific Sessions of the American Diabetes Association said that the FDA will evaluate the vaccine on 150 people who are in an innovative stage of type one diabetes.

The body of an individual with type 1 diabetes does not produce insulin due to the immune system damaging the cells that develop insulin. T cells are produced, and these cells produce issues in the pancreatic islets, where insulin is produced. The vaccine works by removing these T cells. Clients with diabetes injected with the vaccine saw a boost in the levels of a compound called tumor necrosis factor. The increased level of TNF in the system ruins the T cells that are impeding the production of insulin.

In a previous trial, patients were injected with the tuberculosis vaccine twice within a four-week amount of time. The results revealed that the harmful T cells were gone, and some people even started to produce insulin by themselves.

Dr. Denise Faustman, director of the Massachusetts General Healthcare facility Immunobiology Laboratory in Boston, is extremely excited about the outcomes the BCG vaccine has been revealing.

“In the phase I (preliminary) trial we demonstrated a statistically considerable action to BCG, but our goal in (this trial) is to develop an enduring restorative action. We will be working once again with people who have had type 1 diabetes for several years. This is not a prevention trial; rather, we are attempting to create a routine that will treat even advanced illness” discussed Dr. Denise.

There’s a brand-new trial coming which will use the same format as the previous one, on individuals at the age in between 18 and 60. The topics will be injected with the vaccine two times in a duration of 4 weeks, and then once a year for a 4-year time period.